Experimental studies on the effect of chlorpyrifos on rats VI . Population o f intestinal mast Cells and hypersensitivity
DOI:
https://doi.org/10.54172/mjsc.v25i1.1443Abstract
This study performed to investigate the effects of chlorpyrifos ( Insecticides ) on the population o f intestinal mast cells .
Thus a total of 110 male rats were used and divided into four groups The first group was used as a control , the median lethal dose (LD50) was determined according to Aldersy 2005, and appeared to be equal to 81.2 mg/Kg.B.W.
While the second group of rats received an oral daily doses of 1/10 LD50.
The third and fourth groups of rats were administered a single oral dose of 1/10 and 1/30 LD50 respectively .
The mast cells were recognized with their specific morphological characters in the intestinal mucosa, submucosa and muscularis ,under the influence of chlorpyrifos adminstration.
A comparative and statistical investigations revealed a marked degranulation and increase in the population of mast cells in the intestinal layers of experimental rats, compared with the rats of the controlled group.
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