Evaluation of Gallbladder Motilityin Patients With Functional Gallbladder Disorder


  • Salem Awami Department of medicine, Faculty of medicine, Omar EL-Mukhtar University, Al-Bayda- Libya




Irritable bowel syndrome, IBS, Rome III diagnostic criteria, abdominal pain or discomfort, Functional gastrointestinal disorders, FGID


Rome IV defines Functional gastrointestinal disorders (FGID) as disorders of gut-brain interaction. It is a group of disorders classified by gastrointestinal symptoms related to any combination of the following: motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered central nervous system processing. Patients with Gallbladder Functional disorder (GBFD) may have abnormal gastric emptying and colonic transit, suggesting a possible generalized gastrointestinal motility disorder. The presentation of functional gallbladder disorder mimics classic symptoms of biliary pain, 27 patients and 27 healthy volunteers (7 males and 20 females) in each group, age between 21 and 48 years were included into the study, and diagnosis of functional gallbladder disorder was based on Rome III criteria. All patients were given a standard test fatty meal, and Gallbladder volume was calculated manually by using the ellipsoid formula (Dodd’s formula). The pre-meal and post-meal gallbladder volumes and ejection fraction (EF) of the gallbladder (GB) were estimated. The patients and control groups were compared for age, gender, and body mass index. The body mass index in our control and patients was high indicating a prevalence of overweight in both groups. This study demonstrated that fatty meal ultrasound is a cheap, easy to handle, and physiologic. GBFD patients have decreased emptying of gallbladder compared to healthy subjects. GBFD should be considered in patients presented with recurrent right upper quadrant abdominal pain, decreased emptying of gallbladder in the absence of visualized gallstones on abdominal ultrasound, and meeting the Rome III criteria


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Behar, J., Corazziari E., Guelrud M., Hogan W., Sherman S., & Toouli J. (2006). Functional gallbladder and sphincter of Oddi disorders. Gastroenterology,130(5):1498-1509. DOI: https://doi.org/10.1053/j.gastro.2005.11.063

Çay, A., İmamoğlu M., Sarihan H., & Ahmetoğlu A. (2006). Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children. Acta Paediatrica, 95(7):838-842. DOI: https://doi.org/10.1080/08035250500459733

Cooperberg, P., &Burhenne H. (1980). Real-time ultrasonography: diagnostic technique of choice in calculous gallbladder disease. New England Journal Of Medicine 302(23):1277-1279. DOI: https://doi.org/10.1056/NEJM198006053022303

DiBaise, J. K., Richmond B. K., Ziessman H. H., Everson G. T., Fanelli R. D., Maurer A., Ouyang A., ShamamianP., Simons R. J., &Wall L. A. (2011). Cholecystokinin-cholescintigraphy in adults: consensus recommendations of an interdisciplinary panel. Clinical Gastroenterology and Hepatology, 9(5):376-384. DOI: https://doi.org/10.1016/j.cgh.2011.02.013

Drossman, D. A. (1999). The functional gastrointestinal disorders and the Rome II process. BMJ Publishing Group,45(Suppl II):II1–II5. DOI: https://doi.org/10.1136/gut.45.2008.ii1

Francis, G., &Baillie J. (2011). Gallbladder dyskinesia: fact or fiction? Current Gastroenterology Reports 13(2):188-192. DOI: https://doi.org/10.1007/s11894-010-0172-6

Funch-Jensen, P., Drewes A. M., & Madácsy L. (2006). Evaluation of the biliary tract in patients with functional biliary symptoms. World journal of gastroenterology: WJG 12(18):2839. DOI: https://doi.org/10.3748/wjg.v12.i18.2839

Goldblatt, M. I., Swartz-Basile D. A., Al-Azzawi H. H., Tran K. Q., Nakeeb A., & Pitt H. A. (2006). Nonalcoholic fatty gallbladder disease: the influence of diet in lean and obese mice. Journal of gastrointestinal surgery, 10(2):193-201. DOI: https://doi.org/10.1016/j.gassur.2005.07.009

Goussous, N., Maqsood H., Spiegler E., Kowdley G. C., & Cunningham S. C. (2017). HIDA scan for functional gallbladder disorder: ensure that you know how the scan was done. Hepatobiliary & Pancreatic Diseases International, 16(2):197-201. DOI: https://doi.org/10.1016/S1499-3872(16)60188-1

Hansel, S. L., &DiBaise J. K. (2010). Functional gallbladder disorder: gallbladder dyskinesia. Gastroenterol -ogy clinics of North America, 39(2):369-379. DOI: https://doi.org/10.1016/j.gtc.2010.02.002

Hurrell, M. A., Chapman B. A., &Wilson I. R. (1994). Variation in the estimation of gallbladder volume using the sum-of-cylinders method. Investigative Radiology, 29(5):536-539. DOI: https://doi.org/10.1097/00004424-199405000-00002

Irshad, A., Ackerman S. J., Spicer K., Baker N., Campbell A., Anis M., &Shazly M. (2011). Ultrasound evaluation of gallbladder dyskinesia: comparison of scintigraphy and dynamic 3D and 4D ultrasound techniques. American Journal of Roentgenology, 197(5):1103-1110. DOI: https://doi.org/10.2214/AJR.10.5391

Jung, S. W., Joo, M. S., Choi, H. C., Jang, S. I., Woo, Y. S., Kim, J. B., . . . Lee, M. S. (2017). Epigastric symptoms of gallbladder dyskinesia mistaken for functional dyspepsia: Retrospective observational study. Medicine, 96(16). DOI: https://doi.org/10.1097/MD.0000000000006702

Kim, S., &Popkin B. M. (2006). Commentary: Understanding the epidemiology of overweight and obesity—a real global public health concern. International Journal Of Epidemiology, 35, (1):60-67. DOI: https://doi.org/10.1093/ije/dyi255

Kishk, S., Darweesh R., Dodds W. J., Lawson T. L., Stewart E. T., Kern M. K., &Hassanein E. H. (1987). Sonographic evaluation of resting gallbladder volume and postprandial emptying in patients with gallstones. American Journal of Roentgenology, 148, (5):875-879. DOI: https://doi.org/10.2214/ajr.148.5.875

Mahid, S. S., Jafri N. S., Brangers B. C., Minor K. S., Hornung C. A., &Galandiuk S. (2009). Meta-analysis of cholecystectomy in symptomatic patients withpositive hepatobiliary iminodiacetic acid scan results without gallstones. Archives of surgery,144(2):180-187. DOI: https://doi.org/10.1001/archsurg.2008.543

Palasciano, G., Serio G., Portincasa P., Palmieri V., Fanelli M., Velardi A., Gabrieli B. C., & Vinciguerra V. (1992). Gallbladder volume in adults, and relationship to age, sex, body mass index, and gallstones: a sonographic population study. American Journal of Gastroenterology, 87(4) :493-497.

Palotta, N., Corazziari E., Giliotti D., & Torsoli A. (1994). Gallbladder volume variations after meal ingestion. American Journal of Gastroenterology, 89(12) 2212-2216.

Sari, R., Balci M. K., Coban E., &Karayalcin U. (2003). Sonographic evaluation of gallbladder volume and ejection fraction in obese women without gallstones. Journal Of Clinical Ultrasound, 31(7):352-357. DOI: https://doi.org/10.1002/jcu.10191

Tsai, C.-J. (2009). Steatocholecystitis and fatty gallbladder disease. Digestive diseases and sciences 54(9):1857-1863. DOI: https://doi.org/10.1007/s10620-008-0578-2

Varghese, J., LiddellR., Farrell M., Murray F., Osborne D., &Lee M. (2000). Diagnostic accuracy of magnetic resonance cholangiopancreatography and ultrasound compared with direct cholangiography in the detection of choledocholithiasis. Clinical Radiology, 55(1):25-35. DOI: https://doi.org/10.1053/crad.1999.0319

Whitehead, W. E., Palsson O. S., &Simrén M. (2017). Irritable bowel syndrome: what do the new Rome IV diagnostic guidelines mean for patient management?Expert Rev Gastroenterol Hepatol. 11(4):281-283. DOI: https://doi.org/10.1080/17474124.2017.1292130

WHO (1995). Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series, 854.

WHO (2000). Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. WHO Technical Report Series, 894.




How to Cite

Awami, S. . (2018). Evaluation of Gallbladder Motilityin Patients With Functional Gallbladder Disorder. Al-Mukhtar Journal of Sciences, 33(3), 182–189. https://doi.org/10.54172/mjsc.v33i3.208



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