The Relationship of Betatrophin and Kisspeptin with Related Hormones in Women Newly Diagnosed with Polycystic Ovary Syndrome

NoorEmad Alattar; Abeer A. Al–Hadidy

doi:10.54172/mjsc.1458

Authors

NoorEmad Alattar University of Mosul / College of Science / Department of Biology
Abeer A. Al–Hadidy Department of Biology, Faculty of Science, University of Mosul, Iraq.

DOI:

https://doi.org/10.54172/mjsc.1458

Keywords:

Betatrophin, Kisspeptin, PCOS , Insulin re-sistance

Abstract

Polycystic ovary syndrome (PCOS) is one of the most widespread endocrine hormone disorders that affects women of reproductive age. It’s a major public health concern that leads to dysregulations in the reproductive, metabolic, and psychological systems. Anovulation, which has a significant impact on female fertility, and hyperandrogenism are the most characteristic of PCOS. Because of its endocrine role, adipose tissue secretes several proteins called adipokines that work as hormones controlling bodily functions, including resistin, betatrophin, etc. The cases involved in this study were 90 women. For comparison, 30 healthy women with regular periods suitable with age were used as a control group. 30 Obese PCOS women were diagnosed depending on the Rotterdam criteria as group₂, and 30 non-obese PCOS women as group₃. The results showed there was a significant elevate in insulin and insulin resistance and related hormones between groups compared to the control, and a significant increase at (P≤ 0.01) in levels of betatrophin in group₂ compared to the control, with a significant difference between the group₂and group_3, and a significant increase at (P≤ 0.01) in levels of kisspeptin in group₂ compared to the control. No significant difference between group₂ and group₃ and a significant difference between group₃ and the control group.

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