Effect of Hydrocortisone on Blood in Rabbits
Keywords:Hydrocortisone, WBC, RBC, Rabbits, Glucocorticoids
The aim of this study was to test the effect of the drug hydrocortisone sodium succinate on blood picture in white rabbits.The experiment included 30 male Rabbits ranged between 1500-2500g. They were divided into 4 control and treated groups, for different periods of time, depending on the duration of injection. After treatment of the rabbits with a hydrocortisone dose of 10 mg/kg daily for one week and two weeks frequent urination was observed. Swelling of the urinary bladder and congestion of liver was also noticed after slaughtering of the animal. An increase in the amount of adipose tissue around the liver and kidneys in the gradually treated group was observed. Treatment of rabbits with the drug did not lead to change in the weights of rabbits treated for a week. Non significant increase occurred in the weights of rabbits treated for two weeks and those treated gradually, but the suddenly treated group a non significant decrease in rabbits weights was recorded in comparison with their weights before injection. With regard to the blood picture, the treatment for one week and two weeks caused significant increase in the number of red blood corpuscles, white blood cells and platelets count. There had been a significant increase in the packed cell volume of rabbits treated for a week, but the treatment for two weeks did not lead to significant differences. Also the treatment for a week and two weeks lead to a non significant increase in hemoglobin concentration. In the suddenly treated group, the biochemical parameters did not differ significantly from those present in the two weeks treated rabbits, while in the gradually treated group, most of the biochemical parameters returned to their normal values.
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