Conjugated linoliec acids : Synthesis in ruminant animal tissues and their effects on human health
DOI:
https://doi.org/10.54172/mjsc.v26i1.204Keywords:
conjugated linoleic acids, ruminant animals, human healthAbstract
Conjugated linoleic acids represent a group of positional and geometric isomers of linoleic acid cis-9,cis-12C18:2. Ruminant products (meat and milk) are the major source of conjugated linoliec acids due to ruminal biohydrogenation. The cis-9,trans-11C18:2 isomer represent 80-90% of total conjugated linoleic acids. Endogenous synthesis in mammary tissue account for large proportion of cis-9,trans-11C18:2 in milk. Proportion of trans-10,cis-12C18:2 increase under certain dietary conditions. These two isomers exhibit some interesting properties related to human health. The biological properties include limiting the induction and development of malignant tumors, stimulation of immune system and promote growth, lowering blood cholesterol and lowering the body fat mass. Ruminant products rich in these isomers can be considered as functional foods and so the image of these products for consumers can be improved.
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References
Azain, M. J., D. B. Hausman, M. B. Sisk, W. P. Flatt and D. E. Jewell. 2000. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J. Nutr. 130 :1548-1554.
Bauman, D.E., L. H. Baumgard, B. A. Corl and J. M. Griinari. 1999. Biosynthesis of conjugated linoleic acid. In : Proceedings of the American Society of Animal Science, Indianapolis, 1999, 1-15.
Baumgard, L. H., J. K. Sangster and D. E. Bauman. 2001. Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). J. Nutr., 131: 1764–1769.
Benjamin, S. and F. Spener. 2009. Conjugated linoleic acids as functional food: an insight into their health benefits : a Review. Nutrition & Metabolism, 6 : 36-49
Burr, L. L., C. G. Taylor and H. A. Weiler. 2006. Dietary conjugated linoleic acid does not adversely affect bone mass in obese fa/fa or lean Zucker rats. Experimental Biology and Medicine, 231:1602-1609.
Corl, B.A., L. H. Baumgard, D.A. Dwyer, J. M. Griinari, B. S. Phillips and D.E. Bauman. 2001. The role of delta(9)-desaturase in the production of cis-9, trans-11 CLA. J. Nutr. Biochem., 12 : 622-630.
DeLany, J. P., F. Blohm, A. A. Truett, J. A. Scimeca and D. B. West. 1999. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am. J. Physiol. Regul. Integr. Comp. Physiol., 276: R1172-R1179
Devillard, E., F. M. McIntosh, C. J. Newbold, and R. J. Wallace. 2006. Rumen ciliate protozoa contain high concentrations of conjugated linoleic acids and vaccenic acid, yet do not hydrogenate linoleic acid or desaturate stearic acid. Br. J. Nutr., 96 : 697-704.
Garton, G. A., A. K. Lough and E. Vioque. 1961. Glyceride hydrolysis and glycerol fermentation by sheep rumen contents. J. Gen. Microbiol., 25 : 215–225.
Gaullier, J. M., J. Halse, K. Høye, K. Kristiansen, H. Fagertun, H. Vik, and O. Gudmundsen. 2005. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J. Nutr., 135 : 778-784.
Griinari, M. 2005. Conjugated linoleic acid and chicken eggs – A hopeless mismatch? Lipid Technology, 17:127-130.
Griinari, J. M., K. Nurmela, D. A. Dwyer, D. M. Barbano and D. E. Bauman. 1999. Variation of milk fat concentration of conjugated linoleic acid and milk fat percentage is associated with a change in ruminal biohydrogenation. J. Anim. Sci. 77 (suppl. 1): 117–118 (abs.).
Ha, Y. L., J. Storkson and M. W. Pariza. 1990. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Res., 50 : 1097–1101.
Ha, Y. L., N. K. Grimm, M. W. Pariza. 1987. Anticarcinogens from fried ground beef : Heat altered derivatives of linoleic acid. Carcinogenesis, 8 : 1881–1887.
Harfoot, C. G. and G. P. Hazlewood. 1988. Lipid metabolism in the rumen. In : The rumen microbial ecosystem, Ed.: Hobson, P. N., Elsevier, Barking, UK., P 285-322.
Hur, S. J. and G. B. Park. 2007. Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis. European Journal of Pharmacology, 568 : 14-26
Hur, S. J., G. B. Park and S. T. Joo. 2007. Biological activities of conjugated linoleic acid (CLA) and effects of CLA on animal products. Livestock Science, 110: 221-229.
Ip, C., S. F. Chin, J.A. Scimeca and M. W. Pariza. 1991. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res., 51 : 6118–6124.
Jenkins, T. C., R. J. Wallace, P. J. Moate and E. E. Mosley. 2008. Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystem. J. Anim. Sci., 86: 397-412.
Kang, C. W., B. K. An, K. H. Shim, Y. Kobayashi and K. Tanaka. 2003. Excessive dietary conjugated linoleic acid affects hepatic lipid content and muscular fatty acid composition in young chicks. Asian-Aust. J. Anim. Sci. 16 : 1171-1176.
Kelley, N. S., N. E. Hubbard and K. L. Erickson. 2007. Conjugated linoleic acid isomers and cancer. J. Nutr., 137 : 2599-2607.
Kepler, C.R., K. P. Hirons, J.J. McNeill and S. B. Tove. 1966. Intermediates and products of the biohydrogenation of linoleic acid by Butyrivibrio fibrisolvens. J. Biol. Chem., 241 : 1350-1354.
Kim, J. Y and B. H. Chung. 2003.Effects of combination dietary conjugated linoleic acid with vitamin A (retinol) and selenium on the response of the immunoglobulin production in mice. J. Vet. Sci., , 4: 103-108.
Kritchevsky, D., S. A. Tepper, S. Wright, P. Tso, and S. K. Czarnecki. 2000. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J. Am. Coll. Nutr. 19: 472S-477S
Larsen, T. M., S. Toubro, O. Gudmundsen and A. Astrup. 2006. Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. Am. J. Clin. Nutr., 83 : 606 –612.
Lawson, R. E., A. R. Moss and D. I. Givens. 2001. The role of dairy products in supplying conjugated linoleic acid to man’s diet: A review. Nutr. Res. Rev.,14, 153–172.
Munday, J. S., K. G. Thompson and K. A. C. James.1999. Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br J. Nutr. 81:
–255.
Nam, I. S., and P. C. Garnsworthy. 2007. Biohydrogenation of linoleic acid by rumen fungi compared with rumen bacteria. J. Appl. Microbiol. 103:551–556
National Heart Foundation of Australia. 1999. A review of the relationship between dietary fat and cardiovascular disease. Aust. J. Nutr. Diet., 56:Suppl.
Ostrowska, E., M. Muralitharan, R. F. Cross, D. E. Bauman and F. R. Dunshe. 1999. Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. J. Nutr. 129: 2037-2042.
Pariza, M.W. 2004. Perspective on the safety and effectiveness of conjugated linoleic acid. Am. J. Clin. Nutr., 79 : 1132S-1136S
Pariza, M.W. and W. A. Hargraves. 1985. A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene. Carcinogenesis, 6 : 591–593.
Pariza, M. W., Y. Park and M. E. Cook. 2001. The biologically-active isomers of conjugated linoleic acid. Prog. Lipid Res. 40: 283–298.
Pariza, M. W., Y. Park and M. E. Cook. 2000. Mechanisms of action of conjugated linoleic acid: Evidence and speculation . Proc Soc Exptl Biol Med;223:8–13.
Park, Y. 2008. Conjugated linoleic acid (CLA): Good or bad trans fat?. Journal of Food Composition and Analysis . doi:10.1016/j.jfca.2008.12.002
Park Y., J. M. Storkson, K. J. Albright, W. Liu, and M. W. Pariza. 1999. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 34: 235–241.
Park, Y., K. J., Albright, W. Liu, J. M. Storkson, M. E. Cook and M. W. Pariza. 1997. Effect of conjugated linoleic acid on body composition in mice. Lipids, 32 : 853–858.
Roche, H.M., E. Noone, A. Nugent and M. J. Gibney. 2001. Conjugated linoleic acid: A novel therapeutic nutrient?. Nutr Res Rev 14, 173–187.
Ryder, J. W., C. P. Portocarrero, X. M. Song, L. Cui, M. Yu, T. Combatsiaris, D. Galuska, D. E. Bauman, D. M. Barbano, M. J. Charron, J. R. Zierath and K. L. Houseknecht. 2001. Isomer-specific antidiabetic properties of conjugated linoleic acid. Diabetes, 50:1149-1157.
Schmid, A., M. Collomb, R. Sieber and G. Bee. 2006. Conjugated linoleic acid in meat and meat products: A review. Meat Science, 73 : 29–41
Sugano, M., A.Tsujita, M. Yamasaki, M. Noguchi, and K. Yamada. 1998. Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulin in rats. Lipids, 33: 521–527.
Takahashi, K., Y. Akiba, T. Iwata and M. Kasai. 2003. Effects of a mixture of conjugated linoleic acid isomers on growth performance and antibody production in broiler chicks. Br. J. Nutr. 89 : 691-694.
Terpstra, A. H. 2004. Effect of conjugated linoleic acid on body composition and plasma lipids in humans: An overview of the literature. Am. J. Clin. Nutr., 79: 352–361.
Troegeler-Meynadier et Enjalbert. 2005a. Les acides linoléiques conjugués : 1. Intérêts biologiques en nutrition. Revue Méd. Vét., 4 : 207-216.
Troegeler-Meynadier et Enjalbert. 2005b. Les acides linoléiques conjugués : 3. Facteurs de variation des teneurs dans le lait et les produits laitiers. Revue Méd. Vét., 6 : 323-331.
Visonneau, S., A. Cesano, S. A. Tepper, J.A. Scimeca, D. Santoli and D. Kritchevsky. 1997. Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. Anticancer Res., 17: 969–73.
Wang, Y. and P. J. H Jones. 2004. Dietary conjugated linoleic acid and body composition Am. J. Clin. Nutr., 79 : 1153S-1158S.
Wilson, T. A., R. J. Nicolosi, M. Chrysam and D. Kritchevsky. 2000. Conjugated linoleic acid reduces early aortic atherosclerosis greater than linoleic acid in hypercholesterolemic hamsters. Nutr. Res., 20:1795-1805.
Yamasaki, M., H. Chugo, A. Hirao, N. Koyanagi, T. Okamoto, N. Tojo, A. Oishi, T. Iwata, Y.Yamauchi-Sato, T. Yamamoto, K. Tsutsumi, H. Tachibana and K. Yamada. 2003. Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. J. Nutr., 133: 784-788.
Zhang, H., Y. Guo and J. Yuan. 2005. Conjugated linoleic acid enhanced the immune function in broiler chicks. Br. J. Nutr. 94 : 746-752
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