Evaluation of Methods of Gastroesophegeal Reflux Disease Diagnosis in Thawra Teaching Hospital Elbaida –Libya

Authors

  • Faraj Alhomry Mohamed Department of medicine, Faculty of medicine University of Omar Al-Mukhtar, Al-Bayda- Libya
  • Salem M. Awami Department of medicine, Faculty of medicine University of Omar Al-Mukhtar, Al-Bayda- Libya
  • Mykhaylo Kharchevnyk Department of Histopathology Thawra Teaching Hospital, Al-Bayda- Libya

DOI:

https://doi.org/10.54172/mjsc.v33i4.300

Keywords:

reflux esophagitis, GERD, ERD, NERD, Gastroesophageal Reflux Disease Questionnaire (RDQ)Los Angeles classification, endoscopy, microscopic esophagitis

Abstract

Gastroesophageal reflux disease (GERD) results from the reflux of gastric contents, causing symptoms and injury to esophageal tissue. In this study, we evaluate methods of diagnosis of GERD and pattern of clinical, endoscopic, and histological findings in consecutive individuals. Patients were referred to endoscopy unit of Thawra Teaching Hospital, Elbaida-Libya for various reasons, they have Questionnaire-based assessment scales and were examined for the presence of reflux esophagitis, via endoscopy, and microscopic via histopathology. We had  48 patients with mean age of 45.5, 30 female, 18 male. Total patients with microscopic esophagitis were 29 (60.4%), and without microscopic esophagitis 19 (39.6%). The RDQ with a score of ≥ 8 as the diagnostic criteria of GERD, is not a conclusive diagnosis of GERD in isolation, but is of value in determining the need for further investigation. A normal endoscopy does not exclude GERD when endoscopy is inconclusive, adjunctive evidence from biopsy findings can add confidence for a GERD diagnosis. The finding of glandular mucosa without intestinal metaplasia in the distal 2 cm of the tubular esophagus is regarded as normal but indicates a much chronic acid exposure of the lower esophagus.

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References

Alsuwat, O. B., Alzahrani, A. A., Alzhrani, M. A., Alkhathami, A. M., & Mahfouz, M. E. M. (2018). Prevalence of Gastroesophageal Reflux Disease in Saudi Arabia. Journal of clinical medicine research, 10(3), 221. DOI: https://doi.org/10.14740/jocmr3292w

Amano, K., Adachi, K., Katsube, T., Watanabe, M., & Kinoshita, Y. (2001). Role of hiatus hernia and gastric mucosal atrophy in the development of reflux esophagitis in the elderly. Journal of gastroenterology and hepatology, 16(2), 132-136. DOI: https://doi.org/10.1046/j.1440-1746.2001.02408.x

Chandrasoma, P. T., Lokuhetty, D. M., Demeester, T. R., Bremner, C. G., Peters, J. H., Oberg, S., & Groshen, S. (2000). Definition of histopathologic changes in gastroesophageal reflux disease. The American journal of surgical pathology, 24(3), 344-351. DOI: https://doi.org/10.1097/00000478-200003000-00002

Csendes, A., Maluenda, F., Braghetto, I., Csendes, P., Henriquez, A., & Quesada, M. (1993). Location of the lower oesophageal sphincter and the squamous columnar mucosal junction in 109 healthy controls and 778 patients with different degrees of endoscopic oesophagitis. Gut, 34(1), 21-27. DOI: https://doi.org/10.1136/gut.34.1.21

Delavari, A., Moradi, G., Birjandi, F., Elahi, E., & Saberifiroozi, M. (2012). The prevalence of gastroesophageal reflux disease (GERD) in the Islamic Republic of Iran: a systematic review. Middle East journal of digestive diseases, 4(1), 5.

Dent, J. (2007). Microscopic esophageal mucosal injury in nonerosive reflux disease. Clinical Gastroenterology and Hepatology, 5(1), 4-16. e11. DOI: https://doi.org/10.1016/j.cgh.2006.08.006

Dent, J., Brun, J., Fendrick, A., Fennerty, M. B., Janssens, J., Kahrilas, P., . . . Talley, N. (1999). An evidence-based appraisal of reflux disease management—the Genval Workshop Report. Gut, 44(suppl 2), S1-S16. DOI: https://doi.org/10.1136/gut.44.2008.S1

Fan, X., & Snyder, N. (2009). Prevalence of Barrett’s esophagus in patients with or without GERD symptoms: role of race, age, and gender. Digestive diseases and sciences, 54(3), 572-577. DOI: https://doi.org/10.1007/s10620-008-0395-7

Fiocca, R., Mastracci, L., Milione, M., Parente, P., & Savarino, V. (2011). Microscopic esophagitis and Barrett's esophagus: the histology report. Digestive and Liver Disease, 43, S319-S330. DOI: https://doi.org/10.1016/S1590-8658(11)60588-4

Fock, K. M., Teo, E. K., Ang, T. L., Tan, J. Y. L., & Law, N. M. (2009). The utility of narrow band imaging in improving the endoscopic diagnosis of gastroesophageal reflux disease. Clinical Gastroenterology and Hepatology, 7(1), 54-59. DOI: https://doi.org/10.1016/j.cgh.2008.08.030

Gyawali, C. P., Kahrilas, P. J., Savarino, E., Zerbib, F., Mion, F., Smout, A., . . . Roman, S. (2018). Modern diagnosis of GERD: the Lyon Consensus. Gut, 67(7), 1351-1362. DOI: https://doi.org/10.1136/gutjnl-2017-314722

Jain, R., Aquino, D., Harford, W., Lee, E., & Spechler, S. (1998). Cardiac epithelium is found infrequently in the gastric cardia. Gastroenterology, 114, A160. DOI: https://doi.org/10.1016/S0016-5085(98)80648-3

Jones, R., Junghard, O., Dent, J., Vakil, N., Halling, K., Wernersson, B., & Lind, T. (2009). Development of the GerdQ, a tool for the diagnosis and management of gastro‐oesophageal reflux disease in primary care. Alimentary pharmacology & therapeutics, 30(10), 1030-1038. DOI: https://doi.org/10.1111/j.1365-2036.2009.04142.x

Jung, H.-K. (2011). Epidemiology of gastroesophageal reflux disease in Asia: a systematic review. Journal of neurogastroenterology and motility, 17(1), 14. DOI: https://doi.org/10.5056/jnm.2011.17.1.14

Kasap, E., Zeybel, M., Asik, G., Ayhan, S., & Yuceyar, H. (2011). Correlation among standard endoscopy, narrow band imaging, and histopathological findings in the diagnosis of nonerosive reflux disease. J Gastrointestin Liver Dis, 20(2), 127-130.

Kasap, E., Zeybel, M., Aşık, G., Ayhan, S., & Yüceyar, H. (2011). Correlation among standard endoscopy, narrow band imaging, and histopathological findings in the diagnosis of nonerosive reflux disease. J Gastrointestin Liver Dis, 20(2), 127-130.

Katz, P. O., Gerson, L. B., & Vela, M. F. (2013). Guidelines for the diagnosis and management of gastroesophageal reflux disease. The American journal of gastroenterology, 108(3), 308. DOI: https://doi.org/10.1038/ajg.2012.444

Krugmann, J., Neumann, H., Vieth, M., & Armstrong, D. (2013). What is the role of endoscopy and oesophageal biopsies in the management of GERD? Best Practice & Research Clinical Gastroenterology, 27(3), 373-385. DOI: https://doi.org/10.1016/j.bpg.2013.06.010

Lagergren, J., & Lagergren, P. (2013). Recent developments in esophageal adenocarcinoma. CA: a cancer journal for clinicians, 63(4), 232-248. DOI: https://doi.org/10.3322/caac.21185

McDonald, S. A., Graham, T. A., Lavery, D. L., Wright, N. A., & Jansen, M. (2015). The Barrett’s gland in phenotype space. Cellular and molecular gastroenterology and hepatology, 1(1), 41-54. DOI: https://doi.org/10.1016/j.jcmgh.2014.10.001

Mouli, V. P., & Ahuja, V. (2011). Questionnaire based gastroesophageal reflux disease (GERD) assessment scales. Indian Journal of Gastroenterology, 30(3), 108. DOI: https://doi.org/10.1007/s12664-011-0105-9

Pera, M. (2003). Trends in incidence and prevalence of specialized intestinal metaplasia, Barrett’s esophagus, and adenocarcinoma of the gastroesophageal junction. World journal of surgery, 27(9), 999-1006. DOI: https://doi.org/10.1007/s00268-003-7052-2

Quigley, E. M. (1992). 24-h pH monitoring for gastroesophageal reflux disease: already standard but not yet gold?

Richter, J. E. (1994). Severe Reflux Esophagitis. Gastrointestinal Endoscopy Clinics of North America, 4(4), 677-698. DOI: https://doi.org/10.1016/S1052-5157(18)30475-6

Sami, S., & Ragunath, K. (2013). The Los Angeles classification of gastroesophageal reflux disease. Video journal and Encyclopedia of GI Endoscopy, 1(1), 103-104. DOI: https://doi.org/10.1016/S2212-0971(13)70046-3

Sandhu, D. S., & Fass, R. (2018). Current trends in the management of gastroesophageal reflux disease. Gut and liver, 12(1), 7. DOI: https://doi.org/10.5009/gnl16615

Schindlbeck, N., Wiebecke, B., Klauser, A., Voderholzer, W., & Müller-Lissner, S. (1996). Diagnostic value of histology in non-erosive gastro-oesophageal reflux disease. Gut, 39(2), 151-154. DOI: https://doi.org/10.1136/gut.39.2.151

Sharma, P. (2009). Barrett's Esophagus. New England Journal of Medicine, 361(26), 2548-2556. DOI: https://doi.org/10.1056/NEJMcp0902173

Vakil, N., van Zanten, S. V., Kahrilas, P., Dent, J., Jones, R., & Global Consensus, G. (2006). The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol, 101(8), 1900-1920; quiz 1943 DOI: https://doi.org/10.1111/j.1572-0241.2006.00630.x

Zuberi BF, F. N., Quraishy MS, Af-sar S, KaziLA, Kazim E. (2005). Correlation between clinicalendoscopic and histological findings at esoph-agogastric junction in patients of gas-troesophagealreflux disease. J Coll Physicians Surg Pak, 15, 774-777.

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Published

2018-12-31

How to Cite

Mohamed , F. A. ., Awami , S. M. ., & Kharchevnyk, M. . (2018). Evaluation of Methods of Gastroesophegeal Reflux Disease Diagnosis in Thawra Teaching Hospital Elbaida –Libya. Al-Mukhtar Journal of Sciences, 33(4), 290–297. https://doi.org/10.54172/mjsc.v33i4.300

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