Scrapie in Eastern Libya: Case Report in Sheep

Authors

  • Fawzia F. Abdalla Department of basic veterinary medical sciences, Faculty of veterinary medicine, Omar Al-Mukhtar University, Al-Bayda, Libya https://orcid.org/0000-0002-1611-9693
  • Monier A. Sharif Department of basic veterinary medical sciences, Faculty of veterinary medicine, Omar Al-Mukhtar University, Al-Bayda, Libya

DOI:

https://doi.org/10.54172/mjsc.v37i1.622

Keywords:

Scrapie, Prion, Transmissible Spongiform Encephalopathy, Sheep, Libya

Abstract

Here we report neuropathological features of scrapie cases detected between 2018 and 2022.

Fourteen cases of sheep older than 2 years from several areas in Libya with neurological clinical signs resembling those with Scrapie were submitted to the Veterinary Teaching Hospital at Omar Al-Mukhtar University / Al-Beida. Postmortem examinations were performed on all animals after euthanasia. Samples from different organs were submitted for histopathological examination. Routine Hematoxylin and Eosin stain (HE) was used.

Nine cases showed neuronal vacuolation that is characteristic of Scrapie in sheep. Two cases were suspected for Scrapie and need more advanced methods such as Immunohistochemistry (IHC) to confirm the diagnosis. The other three cases were diagnosed with Rabies, Listeria, and Echinococcus granulosus.

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References

Arnold, M., & Rajanayagam, B. (2020). Will there be any more classical scrapie cases in sheep in Great Britain? A modelling study to predict future cases. Epidemiology & Infection, 148. DOI: https://doi.org/10.1017/S0950268820001855

Babelhadj, B., Di Bari, M. A., Pirisinu, L., Chiappini, B., Gaouar, S. B. S., Riccardi, G., Vaccari, G. (2018). Prion disease in dromedary camels, Algeria. Emerging infectious diseases, 24(6), 1029. DOI: https://doi.org/10.3201/eid2406.172007

Cassmann, E. D., & Greenlee, J. J. (2020). Pathogenesis, detection, and control of scrapie in sheep. American Journal of Veterinary Research, 81(7), 600-614. DOI: https://doi.org/10.2460/ajvr.81.7.600

Chen, C., Lv, Y., Hu, C., Xu, X.-F., Zhang, R.-Q., Xiao, K., Shi, Q. (2020). Alternative complement pathway is activated in the brains of scrapie-infected rodents. Medical microbiology and immunology, 209(1), 81-94. DOI: https://doi.org/10.1007/s00430-019-00641-6

Farias, G., Frohlich, E., Sanhueza, P., Jara, P., & Lecocq, C. (2017). Differential diagnosis of scrapie in post mortem goats by immuno histo chemistry. Journal of Dairy, Veterinary and Animal Research, 5(4), 121. DOI: https://doi.org/10.15406/jdvar.2017.05.00147

Fast, C., & Groschup, M. H. (2013). Classical and atypical scrapie in sheep and goats. Prions and Diseases, 15-44. DOI: https://doi.org/10.1007/978-1-4614-5338-3_2

Gavier-Widén, D., Stack, M. J., Baron, T., Balachandran, A., & Simmons, M. (2005). Diagnosis of transmissible spongiform encephalopathies in animals: a review. Journal of Veterinary Diagnostic Investigation, 17(6), 509-527. DOI: https://doi.org/10.1177/104063870501700601

Greenwood, P. (2002). Federal disease control—Scrapie. The Canadian Veterinary Journal, 43(8), 625.

Guijarro, I. M., Garcés, M., Andrés-Benito, P., Marín, B., Otero, A., Barrio, T., Monzón, M. (2020). Assessment of glial activation response in the progress of natural scrapie after chronic dexamethasone treatment. International journal of molecular sciences, 21(9), 3231. DOI: https://doi.org/10.3390/ijms21093231

Imran, M., & Mahmood, S. (2011). An overview of animal prion diseases. Virology journal, 8(1), 1-8. DOI: https://doi.org/10.1186/1743-422X-8-493

Konold, T., Spiropoulos, J., Thorne, J., Phelan, L., Fothergill, L., Rajanayagam, B., Coates, N. (2020). The scrapie prevalence in a goat herd is underestimated by using a rapid diagnostic test. Frontiers in bioengineering and biotechnology, 8, 164. DOI: https://doi.org/10.3389/fbioe.2020.00164

Llorens, F., Barrio, T., Correia, Â., Villar-Piqué, A., Thüne, K., Lange, P., Bolea, R. (2018). Cerebrospinal fluid prion disease biomarkers in pre-clinical and clinical naturally occurring scrapie. Molecular neurobiology, 55(11), 8586-8591. DOI: https://doi.org/10.1007/s12035-018-1014-z

Monleon, E., Monzon, M., Hortells, P., Bolea, R., Acin, C., Vargas, F., & Badiola, J. (2005). Approaches to Scrapie diagnosis by applying immunohistochemistry and rapid tests on central nervous and lymphoreticular systems. Journal of virological methods, 125(2), 165-171. DOI: https://doi.org/10.1016/j.jviromet.2005.01.013

Nair, R. R., & Johnson, J. K. (2011). Prions and neuro degenerative diseases. African Journal of Biotechnology, 10(13), 2366-2374.

Saegerman, C., Vanopdenbosch, E., & Berkvens, D. (2007). Current status of scrapie. DOI: https://doi.org/10.1079/PAVSNNR20072027

Schreuder, B. (1994). Animal spongiform encephalopathies‐an update part 1. Scrapie and lesser known animal spongiform encephalopathies. Veterinary Quarterly, 16(3), 174-181. DOI: https://doi.org/10.1080/01652176.1994.9694444

Taranukha, N., Bezgina, Y., Fedota, N., Gorchakov, E., Ozheredova, N., Stepanenko, E., Simonov, A. (2020). Ensuring food security and control of sheep and goat scrapie. E3S Web of Conferences, DOI: https://doi.org/10.1051/e3sconf/202021006020

(OIE,2014)https://wahis.oie.int/#/dashboards/country-or-disease-dashboard (Accessed 8 Feb 2022).

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Published

2022-03-31

How to Cite

Abdalla, F. F., & Sharif, M. A. (2022). Scrapie in Eastern Libya: Case Report in Sheep. Al-Mukhtar Journal of Sciences, 37(1), 41–47. https://doi.org/10.54172/mjsc.v37i1.622

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