Experimental Studies on the effects of chlorpyrifos on Rats II. Histochemical changes


  • Ibrahim S. H.. El-durssi Zoology Department / College of science / Omar El-Mukhtar University
  • Ifdial I. O. El-Awami Faculty of Agriculture, Plant Protection Department, Omar Almukhtar University, El-Bieda-Libya
  • Ghyath mahmoud College of veterinary medicine/Omar El-Mukhtar University
  • Fahim A. Benkhaial Food technology department / college of agriculture / Omar El-Mukhtar University




This Study performed to investigate the effect of Chlorpyrifos (one of the most used insecticides)on certain organs in  rats .

The experimental animals were 110 male rats and were divided into four groups: the first group was used to determine the median lethal dose (LD50) which appeared to be equal to (81.2)mg/Kg B.W.  While the second group of rats received an oral daily doses of 1/10 LD50. The third and fourth groups of rats were administered single oral dose of 1/10 LD50 and 1/30 LD50 respectively.

Although histochemical investigation revealed that the epithelial cells of the intestine, liver biliary system and kidney’s tubules both in control and experimental rats contained a mixture of acid and neutral mucopolysaccharidse. This reaction matching the histochemistry of both the mast cells and goblet cells in control and experimental rats.


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How to Cite

S. H. El-durssi, I. ., I. O. El-Awami, I. . ., mahmoud, G. ., & A. Benkhaial, F. (2006). Experimental Studies on the effects of chlorpyrifos on Rats II. Histochemical changes. Al-Mukhtar Journal of Sciences, 13(1), 83–92. https://doi.org/10.54172/mjsc.v13i1.669



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