Experimental Studies on the effects of chlorpyrifos on Rats II. Histochemical changes
This Study performed to investigate the effect of Chlorpyrifos (one of the most used insecticides)on certain organs in rats .
The experimental animals were 110 male rats and were divided into four groups: the first group was used to determine the median lethal dose (LD50) which appeared to be equal to (81.2)mg/Kg B.W. While the second group of rats received an oral daily doses of 1/10 LD50. The third and fourth groups of rats were administered single oral dose of 1/10 LD50 and 1/30 LD50 respectively.
Although histochemical investigation revealed that the epithelial cells of the intestine, liver biliary system and kidney’s tubules both in control and experimental rats contained a mixture of acid and neutral mucopolysaccharidse. This reaction matching the histochemistry of both the mast cells and goblet cells in control and experimental rats.
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