دراسة تجريبية حول تأثير المبيد الحشري كلوربايروفوس على الجرذان البيضاء التغيرات الكيماوية الحيوية لبعض الإنزيمات

Ibrahim  S. H. El-durssi; Ifdial   O.S. El-Awami; Ghyath  S. mahmoud; Fahim A. Benkhaial

doi:10.54172/mjsc.v14i1.681

Authors

Ibrahim S. H. El-durssi Zoology Department / College of science / Omar El-Mukhtar University
Ifdial O.S. El-Awami College of agriculture / Omar El-Mukhtar University, P.O. Box. 919.
Ghyath S. mahmoud College of veterinary medicine, Omar El-Mukhtar University, P.O. Box. 919
Fahim A. Benkhaial Food technology department / college of agriculture / Omar El-Mukhtar University

DOI:

https://doi.org/10.54172/mjsc.v14i1.681

Abstract

This Study performed to investigate the effect of Chlorpyrifos (one of the most used insecticides) on certain enzymes in rats .

Thus a total of 110 male rats were used and experimentally divided into four groups: the first group was used to determine the median lethal dose (LD₅₀) which appeared to be equal to 81.2 mg/Kg B.W. While the second group of rats received an oral daily doses of 1/10 LD₅₀ . The third and fourth groups of rats were administered a single oral dose of 1/10 and 1/30 LD₅₀ respectively.

Biochemical investigations revealed an increase in the level of certain enzymes such as : the alkaline phosphatase (ALP), glutamic oxalic acetic transaminase (GOT), glutamic pyruvic transaminase( GPT), creatine kinase (CK) and lactic dehydrogenase (LDH).

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