Experimental Studies on the effects of chlorpyrifos on Rats V. mast cells and globule leukocytes


  • Ibrahim S. H.. El-durssi Zoology Department / College of science / Omar El-Mukhtar University
  • I. O. El-Awami College of agriculture / Omar El-Mukhtar University, P.O. Box. 919.
  • Ghyath mahmoud College of veterinary medicine/Omar El-Mukhtar University
  • Rafi M. El-Kaseh College of veterinary medicine/Omar El-Mukhtar University




This Study performed to investigate the effects of Chlorpyrifos (one of the most used insecticides)on certain organs of rats .

Thus a total of  110 male rats were used and experiment ally divided into four groups: the first group was used to determine the median lethal dose (LD50) which appeared to be equal to 81.2 mg/Kg B.W.  While the second group of rats received an oral daily doses of 1/10 LD50 . The third and fourth groups of rats  were administered a single oral dose of 1/10 and 1/30 LD50 respectively.

The globule leukocytes were recognized as a cell with specific morphological character which appeared in the epithelia of the mucous membrane of lung and intestine under the influence of chlorpyrifos administration.

The Histochemical studies carried out   indicated that the mucopolysaccharides in both GL and MC granules were a mixture of neutral and acid sulphatedmucopolysaccharide.


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إبراهيم سالم حسين الدرسي(2005) . التغيرات المرضية والنسيجية الكيمياوية الناتجة عن تجريع مبيد الكلوربايروفوس في الجرذان ، أطروحة ماجستير، كلية العلوم ، جامعة عمر المختار ، الجماهيرية الليبية .

Cantin, M. and Veilleux, R.(1972). Globule leukocytes and mast cells in rats exposed to magnesium deficiency . Laboratory investigation , 27: 594-499 .

Culling. G.F.A. (1985). Handbook of histopathological Techniques, Second Edition Betterments, London .

Finn, J.P. and Schwartz , L.W.(1972). Globule leukocytes from a neoplastic lesions in rat. J. Comp. Path. 82, 323-326. DOI: https://doi.org/10.1016/0021-9975(72)90012-6

Kellas, L.M.(1961). Globule leukocytes in pregnant uterus of sheep. Acta. Anatomica, 44, 109-113. DOI: https://doi.org/10.1159/000141713

Kent, J.F. , Baker, B.L., Pliske, E.C. and van Dyke, J.G.(1956).Globule leukocytes in mice with radiation proceeding society of experimental biology and medicine 85, 635-640.

Kirkman ,H.(1950). Globule leukocytes in gastro intestinal tract due to parasitic infection .Lab . Investigation .4: 220-224.

Mahmoud, G.S.(1979). Ovine bronchopulmonary Globule leukocytes. Ph.D. Thesis .Glasgow University U.K.

Mahmoud , G.S.(1990). Pathological and Histochemical changes in the respiratory tract of camel naturally infected with hydated cysts . lbn –Al-Haithem. J. 1.3.

Miller, H.R.R.(1971). Globule leukocytes and mast cells in sheep due to fascioliasis . Laboratory investigation , 24: 348-352.

Miller, H.R.R. , Mussauy , M. and jarrette W.F.H.(1968). In reaction of host to parasitism , edited by saulsby , E.L. New York , Academic Press, Inc.

Murray, M.(1972). Immediate hypersensitivity effect mechanism .II. In vivo reaction , In immunity to animal parasites . E.J.L. Soulsby , ed. PP. 155-190. Academic press, New York and London.

Murray, M., Miller, H.R. and Jarrette , W.F.H. (1968). Ultrastructural studies of globule leukocytes and mast cells in rat. Lab. Investigation. 19: 222-228.

Rahko, T.(1971). Ph.D. Thesis Annales academic seientiarum fennicae , A5, 148 , 1.

Spicer , S.S.(1960). Histochemistry of mast cells in rats. J. Histochem, 8: 18-22. DOI: https://doi.org/10.1177/8.1.18

Whur, P.(1966). Distribution of globule leukocytes in mice, J. Comp. Path . 76: 57-60. DOI: https://doi.org/10.1016/0021-9975(66)90048-X



How to Cite

S. H. El-durssi, I. ., O. El-Awami, I. ., mahmoud, G. ., & M. El-Kaseh, R. . (2007). Experimental Studies on the effects of chlorpyrifos on Rats V. mast cells and globule leukocytes. Al-Mukhtar Journal of Sciences, 14(1), 19–26. https://doi.org/10.54172/mjsc.v14i1.682



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