دراسات نسيجية على تطور نمو كبد الجرذان أثناء الحياة الجنينية

Ebtesam M. M. Gheth; Abdusalam M. Aboalhaj; Saad M. S. El-Gharbawy; Abdullah Abdelaaziz

doi:10.54172/mjsc.v18i1.743

Authors

Ebtesam M. M. Gheth Zoology Department, Faculty of Science, Omar Al-Mukhtar University, Libya.
Abdusalam M. Aboalhaj Zoology Department, Faculty of Science, Omar Al-Mukhtar University, Libya.
Saad M. S. El-Gharbawy Faculty of Veterinary Medicine/ Omar El-Mukhtar University
Abdullah Abdelaaziz Zoology Department / Faculty of Science / Alexandria University.

DOI:

https://doi.org/10.54172/mjsc.v18i1.743

Abstract

In this study, the development of the rat's liver was investigated during the embryonic life using 39 fetuses ranged from 9-21 days of age. The hepatic diverticulum begins to appear in eleventh day of fetal life in the form of T-shaped tube evaginated into the mesoderm of the transverse septum. This diverticulum was lined by 2-3 layers of columnar and cuboidal cells that proliferated into irregular buds projected into the mesoderm of the transverse septum.
At 12 day of fetal age the cells of these buds began to differentiate into the primordial liver parenchyma which arranged in the form of several masses and anastomasing cords with several blood spaces in between. The hepatic cords and cell masses were increased at the 13th day of fetal age to occupy the transverse septum.
The primary hepatic sinusoids began to appear at the 12th day of fetal life in the form of irregular blood spaces. At 13 days old, its primary endothelial lining appear. These sinusoids became more differentiated with the increase of age.
The Haemocytoblasts began to appear in the rat liver at the 12th day of fetal life and increased at the 13th day where they fill the lumena of the hepatic sinusoids and appeared as cell aggregations out side them. With the increase of fetal age these cells continue to increase till the time of birth.
The right and left liver lobes began to appear at 12 day of fetal life. By the 16th day the liver appeared as globular structure occupy the majority of the coelom (abdominal cavity). It was formed of four lobes. In 20 days old fetuses the portal areas appeared containg branches of the portal vein, hepatic artery, lymphatic vessel and bile duct.
The hepatic capsule began to appears at 12 day of fetal life. By the 16th day of fetal life the serous capsule appeared to be of one layer of mesothelial cells rested on a fibrous capsule (Glasson's capsule) which formed form a network of reticular fibers.
The reticular fibers appeared in liver parenchyma and capsule during fetal life at the 17th day. The collagen fibers appeared in the capsule in 20 days old fetuses. The elastic fibers did not appear during fetal life except in the wall of blood vessels.

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References

أحمد راشد الحميدي ، عثمان عبدالله الدوخي ومحمد حامد الغندور . (1998) . الأساسيات في عملي أجنة الفقاريات (الوصفي و التجريبي) . الطبعة الأولى . منشورات جامعة الملك سعود .

زينب مختار عبد السميع . (2004) . دراسة تأثير المبيد الحشري " كلوربيرفوس" في إحداث التشوهات الخلقية في الجرذان البيضاء . أطروحة ماجستير . كلية العلوم . جامعة عمر المختار . الجماهيرية .

موفق شريف جنيد . (1998) . علم الجنين . الطبعة الأولى . منشورات جامعة عمر المختار .

Abdalla, K. E. H. (1997). Prenatal development of the liver in the rabbit. Assiut Vet.. Med. J. 36 (72): 1-21. DOI: https://doi.org/10.21608/avmj.1997.183322

Abou-Easa, K. F. K. (1987). Histological and histochemical studies on the liver of developing dromedary Camel (Camelus dromedarius) M. V. Sc. Thesis, Zagazig Univ. (Benha branch).

Anwar, M. E., Hamid, S. H., El-Sayed, E. H. and Zohyd, A. S. E.(1989). A histological study of the postnatal development of the liver of albino rat. Egypt. J. Histol. 12(1): 3-11.

Arey, L. B.(1965). Developmental Anatomy. 7th. Ed. W. B. Saunders Co., Philadelphia, London.

Bancroft, J. D. and Gamble, M. (2002). Theory and practice of histological techniques. Fifth ed. Churchill Livingston. Edinburgh, London and New York.

Bloom, C. and Fawcett, D. (1986). A text book of histology. 11th Ed W. B. Sounders Company. Philadelphia, London. 459- 480.

Carlson, B. M. (1981). Patten's foundation of embryology 4th. Ed. McGraw-Hill Book Company, New York, Toronto.

Clark, W. (1967). The tissues of the body Clarendon Press, Oxford.

Cohen, R. L. (1966). Experimental chemoteratogenesis. Adv. Pharmacol. 4: 263-269. DOI: https://doi.org/10.1016/S1054-3589(08)60101-5

Crossmon, G. (1937). A modification of Mallory connective tissue stain with discussion of the principle involved. Ant. Rec. 69: 33-38. DOI: https://doi.org/10.1002/ar.1090690105

El-Banhawy, M. and Riad, N. (1970). Role of embryonic liver cells in the formation of blood cells in guinea pigs. Ann. Of Zool., 6: 141-151.

El-Banhawy, M. A., El-Ganzuri, M. A., Abd-El-Hamid, M. E. And Abo-shafey, A. (1980). Developmental and experimental studies on the histology of the liver of pigeon. Egypt. T. Histol. 3 (2): 105-112.

Elias, H. (1955). Origin and early development of the liver in various vertebrates. Acta. Hepatol. 3: 1-56.

El-Keshawy, A. H., Awad, A., Abbass, A. and Moustafa, I. A. (1985). Postnatal changes of the liver of female balady rabbitrs in relation of pregnancy and lactation. Zagazig Vet.. J., 12 (2): 360-390.

El-Morsy, A.S., Ahmed,O. S. and Nada,H. F. (1979). Histological study of the human fetal liver. Egypt. J. Histol., 2 (2):139-142.

Fedorendo, N. (1965). Some new data on the course of hemopoiesis in the liver of human embryo and fetus. Stavropol: 54-58. (Qouted from El-Banhawy and Riad, 1970).

Fouad, S. M., El-Keshawy, A. H. and Selim, A. (1984). Histological and Histochemical studies of the prenatal development of the liver of One-humped Camel (Camellus dromedarius). Vet.. Med. J. 32 (1): 313-326.

Godlewski, G., Gaubert-Gristol, R. and Rowy, S. (1992). Liver development in rats during the embryonic period (Carnegie Stage 11-14). Acta Anat. 144: 45-50. DOI: https://doi.org/10.1159/000147284

Godlewski, G., Gaubert-Gristol, R., Rowy, S. Prudhomme, M. (1997). Liver development in the rats during the embryonic period (Carnegie Stage 15-23). Acta Anat. 160:172-178. DOI: https://doi.org/10.1159/000148008

Ham, A. W. (1979). Histology. 8th. Ed. J. B. Lippincatt Company. Philadelphia and Toronto.

Hebel, R., Stromberg, M. W. (1986). Anatomy and Embryology of the laboratory Rat. Worthsee, BioMed, Pp 231-257.

Hertzberg, C. and Orlic, D. (1981). An electron microscopic study of erythropoiesis in fetal and neonatal rabbit. Acta Anat. 110: 164-172. DOI: https://doi.org/10.1159/000145426

Hodgson, E and Levi, P. E. (1997). Textbook of modern toxicology. 2nd. Ed. Applet.on of Lange.

Lu, C. C., Mull, R. L., Lochry, E. A. And Christian, M. S. (1988). Developmental variation of the diaphragm and liver in Fisher 344 rats. Teratol. 37: 571-575. DOI: https://doi.org/10.1002/tera.1420370606

Manson, J. M. Zenick, H. and Costlow, R. D. (1982). Teratology: Test method for laboratory animals. In: principle and method of Toxicology. Student Ed. Edited by Hayes, A. W. Raven press, New York. Pp. 165-182.

Mohamed, A.H., Bareedy, M. H., Ammar, S. M. S., Balah, A. M. and Ewais, M. S. S. (1986). Prenatal development of the Liver of the One-humped Camel (Camellus dromedarius). Egypt. J. Histol., 9 (2): 225-235.

Moustafa, M. N. K. and Ahmed, M. G. (1995). Early development of the liver in dog. Egypt. J. Anat. 18 (1): 35-53.

Naughton, B. A., K., Kolks, G. A., Arce, J. U., Liu, P. Gamba-Vitralo, C., Pilliero, S. J. and Gordon, A. S. (1979). The regenerating liver: A site of erythropoiesis in the adult long-evans rat. Am. J. Anat. 156 (1): 159-167. DOI: https://doi.org/10.1002/aja.1001560117

Nessi, A. C., Bozzini, C. E. and Tidball, M. V. (1981). Fetal hemopoiesis during the hepatic period. L. Relation between in vitro liver organogenesis and erythropoietic function. Anat. Rec. 200: 221-230. DOI: https://doi.org/10.1002/ar.1092000210

Osman, A. H. K., Dougbag, A. S. and Kassem, A. (1984). Organogenesis of the fetal liver of the Egyptian water buffalo (Bos bubalis L.). Egypt. Anat. Soc. 7th. Conference.

Osman, A. H. K., Kassem, A. M. Dougbag, A. S. A. and Moustafa, I. A. (1985). Hemopoiesis in the fetal liver of the Egyptian water Buffalo (Bos bubalis L.) Z. Mikrosk. Anat. Forsch. 99 (2): 219-224.

Patten, B. M. (1948). Embryology of the pig. 3rd. Ed. McGraw- Hill book Company, Inc. New York, Toronto, London.

Severn, C. B. (1972). A morphological study of the development of the human liver. II_ Establishment of liver parenchyma, extra hepatic ducts and associated venous channels. Amer. J. Anat., 133: 85-108. DOI: https://doi.org/10.1002/aja.1001330106

Thomas, D. B. and Yoffey, J. U. (1962). Human fetal hemopoiesis. I- The cellular composition of fetal blood. Brit. J. Hematol. 8: 290- 301. DOI: https://doi.org/10.1111/j.1365-2141.1962.tb06523.x

Valdes-Dapena, M. A. (1979). Liver. In: Histology of the fetus and newborn. Philadelphia; London, Toronto.