The effect of 20% ethanol on liver enzymes activity and the protective efficacy of vitamins C, E,selenium and salymarin in rabbits
DOI:
https://doi.org/10.54172/mjsc.v19i1.815Abstract
This study aimed at investigating the efficacy of vitamins (C and E), selenium and silymarin supplementation in reducing drastic effects of ethanol. Male rabbits were subdivided into three groups: The first was a control group, the second received balanced diet and daily 20% ethyl alcohol as drinking water, the third received the same diet and 20% alcohol and supplemented with a mixed dose of vitamin C (1 mg/100g body weight), Vitamin E (1 mg/ 100 g body weight), Selenium (0.01 mg/ 100 g body weight) and silymarin (1 mg/ 100 g body weight) daily by gastric tube. Blood samples were taken after 2,4,6 and 8 weeks of treatment. Significant ethanol-induced elevations in serum ALT, AST, ALP and LDH activities were observed. Combined treatment of alcohol-treated animals with Vitamins (C and E), selenium and silymarin enhanced marked improvement in the biochemical, physiological indicating their protective effects against toxic effects of ethanol
Downloads
References
Dehmlo, W.C.; Erhard, J. and DeGroote, I.I. (1996). Inhibition of Kupffer-cell function as an explanation for the hepatoprotective properties of silibinin. Hepatology, 23: 749-754. DOI: https://doi.org/10.1002/hep.510230415
Gordis,E(1997).Alchohol problem and puplic health policy.JAMA,278: 1781-1782. DOI: https://doi.org/10.1001/jama.278.21.1781
Goz, B.; Stawe, A.C. and Twnsend, A.J. (1983). Effect of ethanol on alkaline phosphatase activity in Hela cells. Alcohol. Clin. Exp. Res., 7 : 176 -179 . DOI: https://doi.org/10.1111/j.1530-0277.1983.tb05434.x
Hinne. J and Wetherill .G.B(1975).Programmed test in statistic Book 3 Tex 2 Goodness of fit Chapman and hill . London.
Kumar, P. and Clark, M. (2002). Alcohol. In: Kumar and Clark clinical medicine. Pp. 250-251,W.B. Saunders, London, U.K.
Nishimura, M. and Teaschke, R. (1982). Effect of chronic alcohol consumption on the activities of liver plasma membrane enzymes: gamma-glutamyl transferase, alkaline phosphatase and 5’-nucleotidase. Biochem. Pharmacol., 31: 377-381. DOI: https://doi.org/10.1016/0006-2952(82)90185-X
Ramadan, L.A.; Roushdy, H.M.; Abu Senna, G.M.; Amin, N.E. and El-Deshw, O.A. (2002).
Radioprotective effect of silymarin against radiation induced hepatotoxicity. Pharmacol. Res., 45(6): 447-454. DOI: https://doi.org/10.1006/phrs.2002.0990
Saravanan, R; Prakasam, B and pugalindi, K.V(2002) .Influnce of piper beetle on hepatic marker enzymes and tissue antioxidant status in ethanole treatment in Wister rats.J.Med.Food(5):197-204. DOI: https://doi.org/10.1089/109662002763003348
Soto, C.P.; Perez, B.L.; Favari, L.P. and Reyes, J.L. (1998). Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol., 119(2): 125-129. DOI: https://doi.org/10.1016/S0742-8413(97)00198-9
Stranges,S;Frudenhiem ,J,L;frainaro,E;Russell,M;Nochajski,T;hand Trervison,M(2004).Diffrential effects of alchohol DrinkingPattrens on liver enzymeinmen and women .Alchohol Clin.Exp.Res,28(6)949-956. DOI: https://doi.org/10.1097/01.ALC.0000128229.23396.42
Tawfik, S.S.M. (1998). Radio-protective role of antioxidant vitamins in irradiated albino-mice. M. Sc. Thesis, The Institute of Environmental studies and Research, Ain Shams University, Egypt.
Whitfield, J.B. and Martin, N.G. (1985). Individuals differences in plasma ALT, AST and GGT: Contributions of genetic and environmental factors, including alcohol consumption. Enzyme, 33: 61-69. DOI: https://doi.org/10.1159/000469408
Downloads
Published
How to Cite
License
Copyright (c) 2022 وصفي ظاهر، صلاح سليم ابراهيم، محمد جابر، إبراهيم فؤاد
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of the articles Published by Almukhtar Journal of Science (MJSc) is retained by the author(s), who grant MJSc a license to publish the article. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors and cite MJSc as original publisher. Also they accept the article remains published by MJSc website (except in occasion of a retraction of the article).